Endocrine Abstracts

Background: The increase use of abdominal imaging have given rise in incidental discovery of adrenal masses. We report a case of a localized Castleman’s Disease(CD), mimicking an adrenal mass.Case report: A 29-year-old woman was found to have a 6 cm, well-circumscribed and hypoechoic, right adrenal incidentaloma during an abdominopelvic ultrasonography. The CT scan confirmed a suprarenal mass with heterogenous contrast enhancement. Adrenal gland cou...

Background: Overt hypercortisolism is highly associated with venous thromboembolism. Patients with Cushing’s syndrome (CS) typically show an alteration of the intrinsic coagulation pathway, especially an increase in factor VIII (f-VIII), and increased levels of coagulation inhibitors (i.e., antithrombin III) as a compensatory response. Mild autonomous cortisol secretion (MACS) has been variably associated with higher risk of cardiovascular events and mortality compared to...

Background: Patients with Cushing’s syndrome (CS) typically show an alteration in the intrinsic coagulation pathway, leading to an increased risk of venous thromboembolism. Cortisol autonomy has been variably associated with higher risk of cardiovascular events and mortality compared to patients with non-functioning adrenal adenomas (NFA), particularly in women younger than 65 years. However, dedicated studies describing coagulation status in patients with adrenal inciden...

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...

Introduction: Immune-Checkpoint Inhibitors (ICI) are frequently associated with thyroid-related adverse events (AE). Several studies analyzed thyroid disfunctions during ICI therapy, but many aspects remain to be characterized, especially for the most recent anti-PD-1 drugs. The aim of this study is to determine incidence and characteristics of PD-1 inhibitors associated thyroid dysfunction.Methods: We retrospectively analyzed data of patients with advan...

Introduction: Adrenal Insufficiency (AI) is characterized by absolute or relative deficiency of glucocorticoids and adrenal androgen precursors. Patients with AI show an impaired quality of life, metabolic status, immune function and dysregulated circadian genes. Data on sexual function are scarce and often contradictory. The aims of the present study are to evaluate sexual dysfunction (SD) in women and men patients with AI and to investigate the effects of restoring a more ph...

Introduction: The role of Angiopoietin (Ang)/Tie2 kinase pathway in neuroendocrine neoplasms (NENs) has recently received increasing attention, but its clinical role remains unclear. Tie2-receptor inactivation favours chronic inflammation. The balance between its agonist and antagonist regulates its signalling. Aim of this study was to measure serum soluble Tie2 (sTie2) and Ang-2 in patients followed at the NETTARE Unit (NeuroEndocrine TAsk foRcE of ‘Sapienza’ Univer...

Introduction: Cushing’s Syndrome (CS) is associated with an increased frequency and severity of infections. Mild hypercortisolism (MI) from adrenal incidentalomas has been associated with various complications, but data on infections are scarce. Retrospective data on patients with adrenal insufficiency (AI) showed an increased mortality attributed to infections. The approach used was very heterogeneous for all these studies. The aim of the study is to prospectively evalua...

Background: Possible Autonomous Cortisol Secretion (pACS) is a condition found in 1–29% of patients with adrenal incidentalomas. The diagnosis of pACS has been variably associated with an increased risk of cardiovascular events and mortality. However, dedicated studies describing the morphologic and functional cardiac alterations in these patients are lacking.Aim: To compare the cardiovascular features of patients with pACS to those with nonfunction...

Introduction: Glucose metabolism impairment is a common complication of acromegaly. Pegvisomant (PEG) is used as second-line medical treatment in acromegaly. Data from literature suggest a positive effect of PEG on glucose metabolism but a meta-analysis has never been performed.Aim: To address the following questions: i) does PEG affect glucose metabolism? ii) does the effect correlate with disease control?Methods: We performed a m...